文章编号：1005-3611(2000)03-0181-02
A Study on Congitive Function before and after Valproate Treatment in Epileptic Children
MENG Ping,DONG Xuan,FU Ya-ping,YANG Yu-xia(Changzhou First People's Hospital，Changzhou 213003,China)
【Abstract】Objective:To assess the cognitive function of epileptic children be fore and after valproate treatment by use of auditory event-related potentials P 300.Methods:13 patients were tested with auditory event related potentials P300 6 months after treatment.Eight patients were tested after 1-year treatment.Results:there were no statistical differences in the P300 latency,amplitude and reaction time after valproate treatment in epileptic chi ldren.Conclusion:There is no significant effect of valpr oate treatment on the cognitive function of epileptic children.
【Key words】Epilepsy；P300；Valproate
癫痫是儿童的常见疾病之一，严重影响患儿的身心健康，对社会及家庭带来不良后果。目前已肯定P300与认知过程有关，是评价认知功能的一个客观电生理指标。本研究用丙戊酸钠治疗癫痫患儿，并用P300来检测其认知功能的变化，现报导如下。
1 对象与方法
1.1 研究对象
本研究收集我院儿科门诊癫痫大发作患儿共31例，其中男18例，女13例，年龄在5～12岁，用药前均作EEG、IQ及P300检查，服药半年或一年后再作P300检测，部分病例不配合，最终成功检测21例。
1.2 方法
2 结果
服用丙戊酸钠半年组，P300潜伏期和反应时间较服药前明显缩短，P300波幅无显著性改变(表1)。
