Alzheimer型痴呆临床量表检查与MRI边缘系统体积测量的相关研究

　 来源：120online    　 日期：2007-05-09

　　【摘要】目的：探讨Alzheimer型痴呆海马结构、杏仁核、侧脑室颞角等MRI体积与临床量表检查的相关性。方法：使用Siemens 1.5T超导MRI扫描机，对27例临床诊断Alzheimer型痴呆病人的左右侧海马结构、杏仁核、侧脑室颞角等体积进行定量测量，同时对病人进行临床常用量表的检查。结果：MMSE和WMS与杏仁核、海马旁回总体积和侧脑室颞角体积有高度相关性。结论：脑结构测量与脑功能测量有一定的相关。

　　中图分类号：R395.2　　文献标识码：A

　　文章编号：1005-3611(2000)03 -0133-03

A Correlative Study of Volume Measurement MRI of Limbic System with Clinical Scale Examinations in Dementia of Alzheimer's Type

ZHANG Hong-yan,MU Qi-wen,WANG Hua-li,HUANG Gui-lan,SHU liang

　　(Institute of Mental Health,Beijing Medical University.Beijing 100083，China)

　　【Abstract】Objective:To study the correlation between clinical scale measures a nd quantitative MRI of hippocampal formation(HF),amygadala (AM) and temporal d ementia of Alzheimer's type.Methods:Using Siemens 1.5T s uperconductive MRI sca nning machine,volume measurements of the HF,AM and TH on oblique coronal secti ons were assessed for 27 cases of dementia of Alzheimer's type.The patients wer e also administered various clinical scales.Results:The volume of AM,TH and parahippocampals was found to correlate significantly with scores on MMSE and WMS.Conclusion:The volume measurement was found to correlate significantly with function measurement.

　　【Key words】Dementia of Alzheimer's type；Magnetic re sonance imaging(MRI)；Clinical scale

　　1　对象和方法

　　1.1　研究对象

　　1.2　MRI扫描与图像贮存

　　1.3　海马结构、杏仁核、侧脑室颞角体积测量及标准化

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