仙珍骨宝对类固醇性大鼠骨质疏松的生物力学影响

　 来源：120online    　 日期：2007-05-09

　　摘　要：目的：从生物力学角度研究仙珍骨宝胶囊对类固醇性大鼠皮质骨和松质骨的影响。方法：采用3月龄_SD大鼠37只，随机分为基础对照组、年龄对照组、激素模型组和仙珍骨宝低、中、高剂量治疗组。后4组均灌喂醋酸泼尼松4.5mg／kg，2次／周；而3个治疗组还灌喂仙珍骨宝低、中、高剂量。3个月后取股骨和第5腰椎进行股骨干的扭转、三点弯曲和腰椎的压缩试验。结果：激素模型组与年龄对照组比较，股骨干在三点弯曲试验时所承受的载荷减少了17.1％(p＜0.05)，其余的力学参数都出现减少的趋势；应用仙珍骨宝低、中、高剂量治疗组都能防止GC所致的力学性能下降。结论：长期使用GC会使大鼠皮质骨和松质骨的力学性能下降，应用仙珍骨宝胶囊则能扭转其所致的力学性能下降。

EFFECTS OF XIAN ZHEN GU BAO ON BIOMECHANICS OF STEROID-INDUCED OSTEOPOROSIS IN RATS

li Qingnan,Liao Jinmin,Hu Bin(Bone Biology Laboratory, Guangdong Medical College, Zhanjiang 524023 China)

　　Abstract：Objective: To evaluate the effects of Xian Zhen Gu Bao on glucocorticoids(GC)-induced cortical bone and cancellous bone in rats with biomechanical way. Methods: 37 male sprague-Dawley rats were randomly divided into Basal, Aging, Hormone group and lower, middle, high dose group of Xian Zhen Gu bao. the latter 4 groups was given prednisone acetate (4.5mg/kg) twice a week, meanwhile, lower, middle, high dose group of Xian Zhen Gu Baa were respectively given 0.2, 0.4 and 0.8mg/kg/d, 6times a week. The torsion, three-point bending and compression tests were respectively made on femurs and 5th lumbar vertebrae of three groups after 3 months. Results: In GC group, the loads imposed on the femoral middle segments in three-point bending in compression tests were separately decreased by 17.1%(p＜0.05) though the rest parameters tended to decrease, compared with the control group, while the treatment groups used lower, middle, high dose group of Xian Zhen Gu Baa can prevent GC-induced mechanica characters of femurs and lumbar vertebrae in rats from decline. Conclusion: When GC used for a long time, the biomechanical characters of cortical and cancellous bone in the rats would be led to decrease, on the contrary, the decline of GC-induced mechanical characters can be arrested by using Xian Zhen Gu bao.

　　Keywords：prednisone acetate, osteoporosis, femur, lumbar vertebrae, biomechanics基金项目：本课题为山东省中医药管理局资助项目之一参考文献：

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　　［2］胡彬，李青南，李朝阳，等．仙珍骨宝胶囊对泼尼松致雄性大鼠骨质疏松的预防作用．中国中药杂志，1999，24(9)：559～562．

　　［3］Liao J M，Zhu Q A．Lu H J，et a1．Effects of total coumarins of Cnidium monnieri on bone density and biomechanics of glucocorticoids-induced osteoporosls in rats．Acta Pharmacol Sin，1997, 18(6): 519～521

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