复方中药安体欣对大鼠血液流变学的影响

(n=10,X±s)GroupHct/%AI1AI2DICYS/mPaFIB/(g·L-1)Normalsaline37.6±2.76.9±1.617.7±4.30.8±0.227.2±10.33.9±0.4Guipiwan39.2±2.35.5±1.0a12.9±2.7a0.7±0.1a10.0±7.3a4.0±0.4ATXlowdosage36.0±0.7b5.0±1.1a12.0±3.0a0.8±0.317.1±6.6a4.1±0.4ATXmiddledosage37.2±1.24.8±1.2a12.5±3.4a0.9±0.019.1±2.6b3.9±0.2ATXhighdosage41.2±3.04.9±0.3b12.6±0.8b0.8±0.118.6±2.8b4.1±0.2　　aP＜0.05,bP＜0.01vscontrol.表2　安体欣对正常大鼠全血粘度、血浆粘度、高切还原粘度和Casson粘度的影响Tab2　TheeffectsofATXonbloodviscosity(BV),plasmaviscosity(PV),reducedviscosity(RV)andCassonviscosity(CV)ofnormalrats(n=10,X±s)GroupBV/mPa·sPV/mPa·sRVCV/mPa·s230s-15.7s-1230s-15.75s-1Normalsaline4.9±0.732.9±8.31.9±0.215.7±4.144.1±9.23.0±0.6Guipiwan4.4±0.3a24.2±6.3a1.9±0.111.3±2.2a30.2±5.5b3.0±0.2ATXlowdosage4.1±0.1b20.2±4.3b0.4±0.0b11.0±3.3a30.8±9.1a2.8±3.0ATXmiddledosage4.1±0.1b19.2±4.9b0.4±0.0b10.1±3.1a30.7±8.2a2.7±0.2aATXhighdosage4.2±0.1b20.4±1.7b0.4±0.0b9.3±0.2b28.1±1.6b2.8±0.0b　　aP＜0.05,bP＜0.01vscontrol.　　从Tab1，Tab2中可看出，ATX三个剂量均可使全血高切粘度、全血低切粘度、血浆粘度非常显著下降(P＜0.01).ATX高剂量组与对照组相比，可使高切还原粘度，低切还原粘度，红细胞聚集指数AI1,AI2及Casson粘度，Casson屈服应力显著下降(P＜0.01).但对全血细胞比容，红细胞变形指数及纤维蛋白原浓度无明显影响....