血浆蛋白质在生物材料表面吸附时的Vroman效应

　 来源：120online    　 日期：2007-05-09

　　摘要　以吸附时间，血浆稀释倍数，狭窄空间的高度为变量研究纤维蛋白原(Fg)从血浆吸附到生物材料表面时，会发现Fg的吸附出现一最大值，此即Vroman效应。研究证实Vroman效应并非纤维蛋白原所独有的现象，而是一普遍现象，它反映了血浆中的蛋白质对表面有限位点的竞争吸附。我们综述了影响血浆蛋白质在生物材料表面吸附时的Vroman效应的实验因素，Vroman效应的机理以及Vroman效应对于研究血液-材料相互作用的意义。

Vroman Effect of Plasma Protein Adsorption to

　　Biomaterials Surfaces

Huang Jia¹　Yue Yilun¹　Zheng Changqiong²

　　1(Biomaterials and Biotechnology Institute, Department of Polymer Materials and Sciences,Sichuan University,Chengdu　610065)

　　2(Biomedical Engineering Institute, Sichuan University,Chengdu　610065)

　　Abstract　Fibrinogen adsorption from plasma to biomaterials surfaces passes through a maximum when studied as a function of adsorption time, plasma concerntration, or column height in narrow spaces and these are called Vroman effect. Studies have demonstrated that Vroman effect is a general phenomenon of plasma proteins and reflects the competitive adsorption of plasma proteins for a limited number of surface sites. In this paper,the factors affecting Vroman effect, the relationship between contact activation and fibrinogen displacement, and the significance of the Vroman effect with respect to blood-material interactions are reviewed.

　　Key words　Plasma protein　　Adsorption　　Vroman effect

　　1　前　言

　　2　影响血浆纤维蛋白原向生物材料表面吸附的因素

　　影响血浆Fg吸附的因素有：(1)材料表面性能；(2)吸附时间；(3)血浆稀释倍数；(4)温度；(5)缓冲液。因为只有考虑了Fg从血浆中吸附到材料表面时这些影响因素的作用才能正确理解不同实验所得结果。

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