摘要 体内细胞与体外培养细胞差异的关键在于细胞分化，内皮细胞的分化是检测内皮细胞差异的核心问题。内皮细胞在体内分布广泛，其分化表现出极大的异质性，体外培养血管内皮细胞的分化也表现出极大的差异。本文介绍了内皮细胞的胚胎起源、内皮细胞的异质性及影响内皮细胞分化的因素等方面的研究进展，揭示内皮细胞分化的分子机理，将使人们可驾驭其分化，按人们要求使内皮细胞发生特定的分化。
Differentiation of Cultural Endothelial Cells
Liu Xin Shi Yingkang Zhu Bide
Department of Cardiothoracic Surgery, The First University Hospital, West China University of
Medical Sciences, Chengdu 610041
Abstract The disparity of function and ultrastructural characteristics between cells in vivo and cultural cells in vitro has been attributed to the differentiation of cells, so differentiation is the key to detecting the differences between endothelial cells (ECs). The ECs are widely distributed over the entire inner surface of blood vessels in the body and exhibit noticeable heterogeneity. The cultural ECs also show heterogeneity. This is a literature review focusing on the recent advance in researches on the embryonic origin of ECs, the heterogeneity of ECs and the factors that influence differentiation of ECs. Also described is the prospect of studies aimed at elucidating the molecular mechanisms involved in the differentiation of ECs. It is hoped that future studies will enhance the realization of oriented differentiation of ECs.
Key words Culture Endothelial cells Differentiation
1 培养细胞的分化改变
2 血管ECs的胚胎起源
