Biocompatibility of Self-designed Absorbable
Hydroxyapatite/poly(DL-lactide) Composites
Guo Xiaodong Zheng Qixin Du Jingyuan Zen Hui
Quan Dapin Yan Yuhua Li Shipu Li Xiangliang
Department of Orthopaedics, Union Hospital of Tongji Medical University, Wuhan 430022
Biomedical Material Centre, Wuhan University of Technology, Wuhan 430070
Abstract The biocompatibility of self-designed hydroxyapatite/poly (DL-lactide) rods was evaluated both in vitro and in vivo including Ames test, micronucleus test, acute and subacute systemic toxicity test, hemolysis test, hemopexis test and long-term muscle and bone implant test. The results indicate that the material has no toxicity, no stimulation and mutation, and it does not cause hemolysis and hemopexis. Consequently, the biocompatibility of the composite was good.
Key words Bioabsorbable material Hydroxyapatite Poly(DL-lactide) Biocompatibility
可吸收骨折内固定材料可避免二次手术取出而受到人们广泛重视，国外研制的自增强聚羟乙酸(self-reinforced polyglycolide,SR-PG-
A)、自增强聚L-乳酸(self-reinforced polylev-
olctide,SR-PLLA)及非增强聚L-乳酸(PLL-
1 材料与方法
