The Biocompatibility of Chinese Nitinol Alloy Intravascular Stent
Tong Jian Su Hongxi Li Gongsong
Department of Cardio-thoracic Surgery, Zhujiang Hospital,First Military Medical University,Guangzhou 510282
Department of Cardiovascular Surgery, PLA General Hospital, Beijing
Abstract The aim of this study was to evaluate the biocompatibility of Chinese nitinol alloy intravascular stent. Sixteen Chinese nitinol alloy intravascular stents with 4mm ID were implanted in the left and right iliac arteries of 8 normal dogs and were observed for one to six months. The results showed that the stents implanted were completely covered by a thin layer of the neointima after one month and the surface of neointima was covered by a monolayer of endothelium-like cells.These suggest that the Chinese nitinol alloy has very good biocompatibility.
Key words Nitinol alloy Intravascular stent Biocompatibility
近年国外学者应用不锈钢丝制作成血管内支架，预防和治疗经皮血管腔内成形术(PTA)和经皮冠状动脉腔内成形术(PTCA)后的急性闭塞及再狭窄，取得了满意的疗效［1，2］。但该成形支架及导管装置价格昂贵。本实验采用国产钛镍形状记忆合金丝制作成血管腔内支架，通过自制导管装置，将其置入正常犬的双侧髂动脉，以观察国产钛镍合金血管内支架的生物相容性，为过渡到临床应用提供实验依据。
1 材料和方法
钛镍合金血管腔内支架由北京有色金属研究总院提供，其规格为钛44.4 wt%，镍55.6 wt%，相变温度35～40 ℃，钛镍丝径为0.28 mm，支架内径为4 mm，长5 mm，密螺距。自制导管装置由外鞘为8F动脉穿刺扩张器和内置的5F心导管组成。实验动物选用12～21 kg的健康杂种犬8只。
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