Histogenesis and development of membranous basal cell adenoma of the salivary gland
YU Guangyan
(Department of Oral and Maxillofacial Surgery,School of Stomatology,Beijing Medical University,Beijing 100081,China)
Juergen Ussmueller
(Institute of Pathology University of Hamburg MartinistraBe 52
D-20246 Hamburg Germany)
Karl Donath.
(Institute of Pathology University of Hamburg MartinistraBe 52
D-20246 Hamburg Germany)
Abstract：Objective：To investigate the histogenesis and development of membranous basal cell adenoma in the salivary glands.Methods：A histological and immunohistochemical study was carried out on 12 cases of membranous basal cell adenoma in the salivary glands.Results：In 4 cases,multiple focal proliferations of striated ducts in the surrounding salivary gland were conspicuous,which allowed tracing the development of the tumors from their origin.The earliest changes were characterized by hyperplasia of the basal cells of striated ducts.Continuous ductal proliferation lead to the formation of microadenomas.Conclusions：Proliferation of basal cells of the striated ducts apparently participate in,and play a main role in the histogenesis of some membranous basal cell adenomas of the salivary glands.
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