食管癌组织中p53蛋白表达的临床意义

　 来源：120online    　 日期：2007-05-07

　　【摘要】　目的：探讨p53蛋白表达在食管癌中的临床意义。方法：用鼠抗人p53单克隆抗体，以SP免疫组化法检测p53蛋白。结果：p53蛋白阳性表达率为56.3%，其表达与肿瘤大小、TNM分期、有无淋巴结转移无关(P＞0.05)，与肿瘤分化程度有关(P＜0.01)。p53蛋白阳性组与阴性组比较，其术后生存率有显著差异(P＜0.01)。结论：食管癌组织中p53蛋白表达与肿瘤大小、TNM分期及有无淋巴结转移无关，与肿瘤分化程度密切相关，并可用于判断预后。

　　中图分类号：R735.1；R730.43　　　　文献标识码：A

　　文章编号：1009-4571(2000)01-0019-02

The clinical significance of p53 Protein expression in esophageal carcinoma

PENG Yan　ZHENG He-sen　WANG li-quan　et al

　　（Department of surgery,Liaocheng Demobilized soldier Hospital,Liaocheng 252000）

　　【Abstract】　Objective：To study the expression of p53 protein and its clinical significance in esophageal carcinoma.Methods：To investigate p53 protein expression with mouse anti-human p53 monoclonal antibody by SP immunohistochemical method.Results：The positive rate of p53 protein expression in esophageal carcinoma was 56.3%.Its expression had no statistical correlation with tumor length,TNM stage or lymph node metastasis (P＞0.05),but had obviously statistical correlation with the degree of tumor differentiation(P＜0.01).The survival rate after operation was obviously different between positive and negative expression of p53 protein (P＜0.01).Conclusions：The expression of p53 protein in esophageal carcinoma had no obvious correlation with tumor size，TNM stage and lymph node metastasis,but had obvious correlation with tumor differentiation.It may be used in evaluating prognosis of esophageal carcinoma.

　　【Key words】　esophageal carcinoma；p53 protein

　　为了探讨食管癌p53蛋白表达的临床意义，对食管癌石蜡包埋标本进行p53蛋白测定，并与临床资料进行相关性分析，总结报告如下。

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