Study on the Association Between HLA and Erythema Multiforme
JIANG Haiyan，SONG Fangji，ZHAI Ning，et al.
（Department of Dermatology, The First Hospital, China Medical University, Shenyang 110001）
【Abstract】Objective To investigate the association of erythema multiforme(EM) with HLA. Methods ClassⅠ HLA antigen was detected by serology and classⅡ HLA gene typing was performed by PCR－ SSP method, thirty patients with EM were detected. Results The frequency of HLA－ A30＋ 31 and HLA－ B13 antigen was significantly higher in EM patients than that in the controls(A30＋ 31:Pc＜0.01,RR=6.64;B13:Pc＜ 10－ 3,RR=7.88).The frequency of HLA－ DQB1＊ 04 gene was markedly higher in patients than that in the controls (DQB1＊ 04: Pc＜ 10－ 3,RR=4.8125),while the frequency of DQB1＊ 03 gene was significantly lower in EM patients than that in the controls(DQB1＊ 03:Pc＜ 10－ 5,RR=0.07). Conclusion There is a positive correlation between EM and HLA－ A30＋ 31、 B13、 DQB1＊ 04,with a negative correlation between EM and HLA－ DQB1＊ 03.
【Key words】 Erythema， multiforme HLA antigens Polymerase chain reaction
自1967年Amiel开创了HLA与疾病的相关性研究以来[1],目前已报道有100多种疾病与各种HLA抗原有关。为探索多形红斑发病机理中免疫遗传因素的作用,我们进行了多形红斑与HLA相关性的研究。现将结果报道如下。
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