禁食应激对肝、肠组织Fe、Mg、Zn、Cu含量的影响

　 来源：120online    　 日期：2007-05-07

　　【摘要】　目的　观察禁食豚鼠不同时期肝和小肠组织Fe、Mg、Zn、Cu含量的变化，以揭示禁食应激对肝、肠组织金属元素代谢的影响。方法　短毛种豚鼠24只，随机分为4组，正常组和实验组1、2、3，实验组分别禁食24、48、72小时。结果　1.肝组织内Fe、Mg和小肠组织中Fe、Mg、Zn水平随禁食时间的延长而下降。2.肝组织中Zn、Cu水平则随禁食时间的延长而上升。3.小肠组织内Cu水平在禁食早期明显上升，以后下降至正常。均为P＜0.05。结论　禁食应激可影响消化系统多种金属元素的代谢；消化系统内Fe、Mg、Zn、Cu水平与机体应激反应之间存在一定的联系。

Levels of Fe,Mg,Zn and Cu in liver and small intestine on starveting guinea pigs

Sui Jian，Ren Chunlan. Department of Pathophysiology, Zhenjiang Medical College, Zhenjiang 212001

　　【Abstract】　Objective To study the relationship between starvation and the metal elements in liver and small intestine. Method Twenty-four guinea pigs were divided randomly into no-starving group as comparison, starving 24hr group，48hr group and 72hr group as experimental groups.The effect of starvation on Fe,Mg,Zn,Cu levels in liver and small intestine of guinea pigs was observed.Results 1.level of Fe,Mg in liver,Fe,Mg,Zn level in small intestine lowered along with the continunity of hunger. 2.Zn，Cu level in liver increased in experimental groups. 3.Cu level in small intestine increased at the early stage of starvation, decreased to normal level afterwards.Conclusion 1. starvation do effect distribution and metabolism of Fe,Mg,Zn,Cu levels in digest system.2. Fe,Mg,Zn,Cu levels in digest system and stress response may have interelation.

　　【Key words】　Starvation　Stress　Liver　Small intestine

材料与方法

　　一、实验动物　本院实验动物中心繁殖短毛种豚鼠24只，4～5月龄，体重302.2±30.7克，雌雄各半，随机平均分成四组，①对照组：为不禁食组，②实验组1：24小时禁食，③实验组2：48小时禁食，④实验组3：72小时禁食。对照组动物自由进食，各实验组动物自由饮水。

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