The effect of electro-acupuncture on behavior and brain's monoamine neurotransmitters of rat
Jin Guangliang, Su Jing, Ding Shiqin, et al.Beijing University of Traditional Chinese Medicine, Beijing 100029
【Abstract】 Objective In order to study the effect and mechanism of rat with electro-acupuncture at BAIHUI, YINTANG points. Methods Male Sprague-Dawley rats were randomly allocated to four groups as follows: control, amitriptyline, electro-acupuncture at BAIHUI, YINTANG points and electro-acupuncture at control points. After 10 days, observe the behavior of rat in opened-field and shuttle-box, and the concentration of monoamine neurotransmitters and their metabolites in rat brain were determined by HPLC-ECD. Results The shock time of rat which is electro-acupuncture at BAIHUI, YINTANG points was decreased, the DOPAC in cortex was significantly decreased; and the 5-HT/5-HIAA in striatum was significantly increased. Conclusions It is sugguested that electro-acupuncture at BAIHUI, YINTANG points could affect the behavior of rat, which is related to increased active of 5-HT and DA type neuron.
【Key words】 Electroacupuncture BAIHUI point YINTANG point Behavior Biogenic amine neurotransmitters
材料与方法
三、穿梭行为观察：按文献［4］的方法改进。将大鼠放入穿梭箱内适应3min后，开始给以由计算机控制的蜂鸣及电击。程序为：蜂鸣4秒，电击4秒，电压30V，每次间隔30秒，共30次。
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