维生素B6缺乏对大鼠学习记忆的影响及有关机制的探讨

　 来源：120online    　 日期：2007-05-07

　　【摘要】　目的　观察维生素B₆(VB₆) 缺乏对生长期大鼠学习记忆功能的影响，并从脑发育、神经递质方面探讨有关机制。方法　 用避暗法检测大鼠学习记忆行为，用荧光法测定脑组织核酸和单胺类神经递质含量。结果　 VB₆缺乏组大鼠学习记忆能力明显下降，同时脑中多巴胺和5-羟色胺显著降低，而脑发育有关指标未见异常改变。结论　 VB₆可通过调节脑中单胺类神经递质水平，影响大鼠学习记忆能力。

Effects of vitamin B₆ on learning and memory of rats and the mechanisms involved

Hong Yan, Wang Donglan, Li Shutian,et al.

　　(Institue of Health and Enviornment Medicine ,Tianjin 300050)

　　【Abstract】　Objective　The effects of vitamin B₆ on learning and memory of growing rats and the mechanisms involved were observed in the present study. Methods　The behaviors of learning and memory in rats were studied with step- through test, the contents of nucleic acid and monoamino neurotransmitters in brain were determined by fluorescent method.Results　The VB₆-deficient group rats showed that the learning and memory disability,the contents of dopamine and 5- hydroxytryptamine in brain were obviously less than those of the other two groups, but the protein、DNA and RNA contents were no significiantly different between three groups.Conclusions　Vitamin B₆ affect learning and memory of the rats through modulating the synthesis of monoamino neurotransmitters in brain.

　　【Key words】 Vitamin B₆　Learning and memory　Brain development　Neurotransmitters

　　材料与方法

　　一、实验动物分组与饲养

　　二、观察指标及测定方法

　　1. 红细胞天门冬氨酸氨基转移酶(AST)活性系数：酶偶联法^［5］

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